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Filtered Search Results
Medchemexpress LLC Selumetinib | 606143-52-6 | 99.6% | C17H15BrClF4O3 | 200 MG
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Selumetinib is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier. This compound causes a time- and dose-dependent reduction in DNA synthesis and cell viability, inducing growth arrest and apoptosis associated with ERK inactivation.
- Selective, non-ATP-competitive oral MEK1/2 inhibitor
- Inhibits ERK1/2 phosphorylation
- Penetrates the blood-brain barrier
- Induces growth arrest and apoptosis
- Shows anti-proliferative effects
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Medchemexpress LLC B7-H2/ICOSLG Mouse 5ug
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B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag
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Apexbio Technology LLC Tirapazamine(Synonyms: SR-4233, WIN 59075, Tirazone, TPZ, 3-Amino-1,2,4-benzotriazine 1,4-dioxide), 200mg, CAS: 27314-97-2.
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Tirapazamine (CAS 27314-97-2) also known as SR259075 Win59075 or SR4233 is an investigational anticancer agent selectively activated under hypoxic conditions characteristic of solid tumors The compound is bioreduced in hypoxic tumor microenvironments to cytotoxic free radicals leading to cellular damage Tirapazamine downregulates hypoxia-inducible factor-1 (HIF-1 ) thereby influencing pathways associated with tumor adaptive mechanisms to hypoxia Combined treatment with tirapazamine and topoisomerase I inhibitors (such as SN-38 the active metabolite of irinotecan) enhances apoptosis via mitochondria-mediated caspase activation and weakened DNA repair signaling Preclinical investigations including hepatocellular carcinoma xenografts confirm this enhanced tumor suppression Clinical trials evaluating tirapazamine s anticancer efficacy are ongoing
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Apexbio Technology LLC MHY1485 326914-06-1 200mg
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MHY1485 (CAS 326914-06-1) is a potent activator of mammalian target of rapamycin (mTOR) a serine/threonine kinase critical for cellular growth metabolism and survival pathways By activating mTOR signaling MHY1485 inhibits autophagy initiation and disrupts the fusion step between autophagosomes and lysosomes resulting in accumulation of autophagic marker LC3-II and enlarged autophagic structures In cultured rat Ac2F hepatic cells MHY1485 suppresses basal and starvation-induced autophagic flux Additionally MHY1485 treatment promotes ovarian follicular development and increases explant growth in mouse ovarian culture models providing a useful tool in biomedical research of mTOR signaling and reproductive biology
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Ambeed Ferrocenemethanol
Ferrocenemethanol, 1273-86-5, 98%
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Medchemexpress LLC Aripiprazole | 129722-12-9 | 99.95% | 200 MG
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Aripiprazole is an atypical antipsychotic that acts as a potent and high-affinity dopamine D2 receptor partial agonist. It also functions as an inverse agonist at 5-HT2B and 5-HT2A receptors and exhibits partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. This compound is suitable for research into conditions such as schizophrenia and COVID19.
- Atypical antipsychotic
- Potent and high-affinity dopamine D2 receptor partial agonist
- Acts as an inverse agonist at 5-HT2B and 5-HT2A receptors
- Exhibits partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors
- Can be used for the research of schizophrenia and COVID19
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TARGETMOL CHEMICALS INC Epalrestat 200MG
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Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control. Purity 99.54%
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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.5% | 257.30 | 50 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules containing two ligands connected by a linker: one for an E3 ubiquitin ligase and another for the target protein. Their application involves exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Applicable in cancer and cancer targeted therapy
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Medchemexpress LLC Mexenone | 1641-17-4 | 99.9% | 200 MG
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Mexenone is a potent benzophenone-type UV filter used as a sunscreening agent.
- Potent benzophenone-type UV filter.
- Used for sunscreening.
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Medchemexpress LLC (S,R,S)-AHPC-CO-C9-acid | 2172819-78-0 | 95.0% | 628.82 | 50 MG
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(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. This compound is intended for research use only.
- Functions as an E3 ligase ligand-linker conjugate.
- Can be connected to ligand for protein to form PROTACs.
- Exhibits antiproliferative activity against human NCI-H69 cells.
- Has an IC50 > 40 μM against NCI-H69 cells.
- Appearance: solid, white to off-white.
- Ships at room temperature in continental US.
- Storage conditions: 4°C, protect from light, stored under nitrogen.
- Soluble in various solvents including DMSO, PEG300, Tween-80, Saline, SBE-β-CD, and Corn Oil.
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Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 100 MG
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Sulfo-Cy5 azide is a near-infrared fluorescent probe that exhibits favorable click chemistry reactivity. It is used for fluorescence imaging, tissue and cellular visualization, and site-specific modification of antibodies. It can also be applied for RNA labeling and imaging and conjugated to targeting agents for fluorescence imaging in models of atherosclerosis and breast cancer.
- Near-infrared fluorescent probe
- Favorable click chemistry reactivity
- Enables fluorescence imaging
- Used for tissue and cellular visualization of PD-L1 in tumors
- Allows site-specific modification of anti-PD-L1 antibodies
- Applicable for RNA labeling and imaging
- Can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models
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Medchemexpress LLC Z-LYS-SBZL monohydrochloride | 69861-89-8 | 99.7% | C21H27ClN2O3S | 25 MG
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Z-LYS-SBZL monohydrochloride (α-N-Carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride) is a lysine derivative primarily intended for research use. Amino acids and their derivatives, like this product, are recognized as beneficial ergogenic dietary substances. It is designed to support various biological activities related to physical and mental performance.
- Influences anabolic hormone secretion
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- For research use only
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Apexbio Technology LLC Cyclosporin A 59865-13-3 200mg
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Cyclosporin A is an immunosuppressive agent acting primarily through inhibition of cyclophilins intracellular peptidyl-prolyl isomerases with a reported IC50 of 7 nM Cyclophilins regulate mitochondrial permeability transition pore (MPTP) opening intracellular calcium signaling and NFAT transcriptional activation pathways Cyclosporin A s ability to inhibit calcineurin-NFAT signaling in T-cell activation leads to suppression of inflammatory immune responses indicating potential use in autoimmune disorder research Additionally it modulates cell apoptosis and survival mechanisms in diverse models including retinal ischemic injury viral entry (HBV HCV) and tumor biology in colon cancer cell lines
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eMolecules 4-Hydroxyquinoline-6-carbonitrile | 219763-82-3 | MFCD08063203 | 1g
Apollo Scientific | 4-Hydroxyquinoline-6-carbonitrile | 1g | 562462240 | OR350490 | 96.000 | 219763-82-3 | MFCD08063203 | 170.171 | C10H6N2O
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Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 200mg, CAS: 519-02-8.
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Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
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